Urepearl Plus Cream


Second-class OTC drug


Medicated Moisturizer for Dry Skin

  • This medicine contains a natural moisturizing factor, urea and vitamin E (tocopheryl acetate) which help to maintain water, and smoothen and moisturize dry skin.
  • It contains three types of components as anti-itching active ingredients.
  • It is a cream which fits to the skin and spreads smoothly.
Packaging Manufacturer's suggested retail price
80g JPY 2,024
(JPY 1,840 excluding tax)


The following precaution should be observed.
(If not observed, it may aggravate the current symptoms or increase the risk of adverse reactions.)
Do not apply to the following areas.

  1. Around the eyes, mucous membranes (e.g. mouth, nasal cavity, vagina, etc.)
  2. Inflammation or wounds
  3. Severe skin sore or cracking of the skin


  1. The following persons should consult a physician, pharmacist or registered distributor before using the medicine.
    1. Persons under treatment by a physician
    2. Persons with a history of allergic symptoms (e.g. rash, redness, itching, contact dermatitis, etc.) or irritation symptoms due to any drug
  2. The following symptoms may be adverse reactions to the medicine. If any of these symptoms occur, discontinue the use of the medicine immediately, and consult a physician, pharmacist or registered distributor with this leaflet.
    Affected body systemSymptoms
    Skin Contact dermatitis, rash, redness, itching, irritation (pain, feeling hot, tingling sensation), swelling, scab-like skin exfoliation
  3. If symptoms do not improve after using the medicine for about two weeks, discontinue the use of the medicine, and consult a physician, pharmacist or registered distributor with this leaflet.


Dry skin accompanied by itching (xeroderma in the elderly/adults, dry skin in children)


Apply an appropriate amount to the affected area once to several times daily.


  1. Be careful not to get the medicine into the eyes. If the medicine gets into the eyes, immediately wash with water or lukewarm water. If symptoms are severe, consult an ophthalmologist.
  2. For children, use under parental guidance.
  3. For external use only.
  4. Clean the affected area and surrounding skin before use.
  5. Follow the prescribed dosing instructions.
  6. As this is not a cosmetics, use only for the affected areas listed in the indications, and do not use on the face for the purpose of basic skin care, etc.


This is a cream containing the following active ingredients per 100 g.
Urea 10.0 g, Diphenhydramine Hydrochloride 1.0 g, d-Camphor 1.0 g, Lidocaine 2.0 g, Tocopherol Acetate 0.3 g

Inactive Ingredients:
Methyl Paraben, Butylated Hydroxytoluene (BHT), Glyceryl Triisooctanoate, Octyldodecyl Myristate, Cholesterol, Methyl Polysiloxane, Stearyl Alcohol, Cetanol, Behenyl Alcohol, Glyceryl Stearate, Sorbitan Stearate, Polyoxyethylene Behenyl Ether, Macrogol Stearate, Polyoxyethylene CetyletherSodium Phosphate, Glycine, DL-Alanine, Sodium Chloride, Glycerin, Sodium Lactate, Lactic Acid, Purified Water


  1. Stopper tightly and store in a cool place, away from direct sunlight.
  2. Keep out of the reach of children.
  3. Do not transfer to other container. (It may cause misuse or change the quality.)
  4. Do not touch the eyes and mucous membrane with hands attached the medicine.
  5. Do not use the product past the expiration date printed on the outer box and the container.


Manufactured and Distributed by: Otsuka Pharmaceutical Factory Inc.
Dosage form Cream
Packaging unit 80 g
JAN Code 4987117140125
Expiration 3 years


For inquiries, please contact the shop where you purchased the product or the following:
Distributor Contact: Customer Relations Office, Taiho Pharmaceutical Co., Ltd.
1-27 Kandanishiki-cho, Chiyoda-ku, Tokyo, 101-8444, Japan
Phone: 0120-4527-66 Business hours: 9:00-17:00 (Excluding weekends and holidays)
Website: https://www.taiho.co.jp/

Manufactured and Distributed : Otsuka Pharmaceutical Factory Inc.